Molecular Profile Detail

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Profile Name SMO wild-type
Gene Variant Detail

SMO wild-type (no effect)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
SMO wild-type stomach cancer predicted - sensitive Vismodegib Preclinical Actionable In a preclinical study, Vismodegib (GDC-0449) inhibited Hedgehog pathway signaling, increased apoptosis, and decreased proliferation of a gastric cancer cell line in culture (PMID: 26676867). 26676867
SMO wild-type medulloblastoma sensitive Taladegib Preclinical Actionable In a preclinical study, LY2940680 was demonstrated to bind to the Smo receptor and inhibit hedgehog signaling in a human medulloblastoma tumor cell line (Cancer Research: April 15, 2011; Volume 71, Issue 8, Supplement 1, Abstract #2819). detail...
Clinical Trial Phase Therapies Title Recruitment Status