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|Profile Name||SMO wild-type|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|SMO wild-type||stomach cancer||predicted - sensitive||Vismodegib||Preclinical||Actionable||In a preclinical study, Vismodegib (GDC-0449) inhibited Hedgehog pathway signaling, increased apoptosis, and decreased proliferation of a gastric cancer cell line in culture (PMID: 26676867).||26676867|
|SMO wild-type||medulloblastoma||sensitive||Taladegib||Preclinical||Actionable||In a preclinical study, LY2940680 was demonstrated to bind to the Smo receptor and inhibit hedgehog signaling in a human medulloblastoma tumor cell line (Cancer Research: April 15, 2011; Volume 71, Issue 8, Supplement 1, Abstract #2819).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|