Molecular Profile Detail


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Profile Name ETV6 - JAK2 JAK2 R975G
Gene Variant Detail

ETV6 - JAK2 (gain of function)

JAK2 R975G (gain of function - predicted)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ETV6 - JAK2 JAK2 R975G hematologic cancer resistant Pyridone 6 Preclinical Actionable In a preclinical study, immune cells expressing ETV6-JAK2 with the R975G mutation demonstrated resistance to Pyridone 6 (CMP6) in culture (PMID: 22916261). 22916261
Clinical Trial Phase Therapies Title Recruitment Status