Molecular Profile Detail

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT04082572	Phase II	Pembrolizumab	Pembrolizumab Before Surgery for the Treatment of Mismatch Repair Deficient Locally Advanced Solid Cancers	Active, not recruiting	USA	0
NCT03911557	Phase II	Durvalumab + Tremelimumab	Durvalumab and Tremelimumab Combination in Somatically Hypermutated Recurrent Solid Tumors	Active, not recruiting	USA	0
NCT02888743	Phase II	Durvalumab + Tremelimumab	Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer	Active, not recruiting	USA \| CAN	0
NCT02912559	Phase III	Atezolizumab + Fluorouracil + Leucovorin + Oxaliplatin Fluorouracil + Leucovorin + Oxaliplatin	Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair	Active, not recruiting	USA \| DEU	1

Profile Name	MSH6 loss
Gene Variant Detail	MSH6 loss (loss of function)
Relevant Treatment Approaches