Molecular Profile Detail

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
TP53 R273H TP53 P309S	colorectal cancer	sensitive	NSC59984	Preclinical - Cell culture	Actionable	In a preclinical study, treatment with NSC59984 induced Tp53 pathway signaling, degradation of mutant Tp53, and cell death in a colorectal cancer cell line harboring TP53 R273H and TP53 P309S in culture (PMID: 26294215).	26294215
TP53 R273H TP53 P309S	colorectal cancer	sensitive	Cisplatin + NSC59984	Preclinical - Cell culture	Actionable	In a preclinical study, the combination of Platinol (cisplatin) and NSC59984 worked synergistically to decrease viability of a colorectal cancer cell line harboring TP53 R273H and TP53 P309S in culture (PMID: 26294215).	26294215
BRAF V600E PIK3CA P449T TP53 R273H	colorectal cancer	sensitive	PD-0325901 + Sapanisertib	Preclinical - Cell line xenograft	Actionable	In a preclinical study, Sapanisertib (MLN0128) and PD-0325901 synergistically inhibited Erk and PI3K signaling and growth of colorectal cancer cells harboring BRAF V600E, PIK3CA P449T, and TP53 R273H in culture and in cell line xenograft models, but did not have synergistic effect on apoptosis (PMID: 26272063).	26272063

Profile Name	TP53 R273H
Gene Variant Detail	TP53 R273H (loss of function)
Relevant Treatment Approaches	p53 Activator p53 Gene Therapy