Profile Response Detail


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Molecular Profile BRAF G469A
Therapy Vemurafenib
Indication/Tumor Type lung non-small cell carcinoma
Response Type resistant


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF G469A lung non-small cell carcinoma resistant Vemurafenib Case Reports/Case Series Actionable In a Phase II trial, Zelboraf (vemurafenib) treatment did not result in response in the cohort of 15 non-small cell lung cancer patients with non-V600 BRAF mutations, which included 3 patients harboring BRAF G469A, and enrollment in this cohort was discontinued (PMID: 31959346; NCT02304809). 31959346
BRAF G469A lung non-small cell carcinoma resistant Vemurafenib Preclinical - Cell culture Actionable In a preclinical study, a non-small cell lung cancer cell line harboring BRAF G469A demonstrated resistance to induction of apoptosis by Zelboraf (vemurafenib,) and treatment with Zelboraf (vemurafenib) was not effective in inhibiting growth in culture (PMID: 25706985). 25706985
PubMed Id Reference Title Details
(25706985) Trametinib with or without vemurafenib in BRAF mutated non-small cell lung cancer. Full reference...
(31959346) Vemurafenib in non-small-cell lung cancer patients with BRAFV600 and BRAFnonV600 mutations. Full reference...