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Molecular Profile FGFR1 amp
Therapy Infigratinib
Indication/Tumor Type lung squamous cell carcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 amp lung squamous cell carcinoma sensitive Infigratinib Phase I Actionable In a Phase I trial, patients with lung squamous cell carcinoma harboring an FGFR1 amplification demonstrated a disease control rate of 50% (18/36) when treated with Infigratinib (BGJ398), resulting in 14 patients with stable disease and 4 patients with a partial response (PMID: 27870574). 27870574
PubMed Id Reference Title Details
(27870574) Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study. Full reference...