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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR1 amp||lung squamous cell carcinoma||sensitive||Infigratinib||Phase I||Actionable||In a Phase I trial, patients with lung squamous cell carcinoma harboring an FGFR1 amplification demonstrated a disease control rate of 50% (18/36) when treated with Infigratinib (BGJ398), resulting in 14 patients with stable disease and 4 patients with a partial response (PMID: 27870574).||27870574|
|PubMed Id||Reference Title||Details|
|(27870574)||Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study.||Full reference...|