Profile Response Detail

Molecular Profile KRAS mutant
Therapy NS1
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive
Create By cstatz
Update By cstatz

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS mutant Advanced Solid Tumor sensitive NS1 Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing a KRAS mutation demonstrated sensitivity to NS1 in culture, resulting in decreased Mapk and Akt signaling and inhibition of cell transformation (PMID: 27820802). 27820802
PubMed Id Reference Title Details
(27820802) Inhibition of RAS function through targeting an allosteric regulatory site. Full reference...