Molecular Profile | STK11 inact mut |
Therapy | CI-1040 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Create By | spatt |
Update By | spatt |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References | STK11 inact mut | Advanced Solid Tumor | sensitive | CI-1040 | Preclinical - Cell culture | Actionable | In a preclinical study, the presence an STK11 loss expression signature, which correlates with STK11 inactivating mutations, was associated with increased sensitivity to CI-1040 (PD184352) in human tumor cell lines in culture (PMID: 27821489). | 27821489 |
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PubMed Id | Reference Title | Details |
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(27821489) | A Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma. | Full reference... |