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Molecular Profile Unknown unknown
Therapy T-3775440
Indication/Tumor Type acute myeloid leukemia
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown acute myeloid leukemia not applicable T-3775440 Preclinical - Cell line xenograft Actionable In a preclinical study, T-3775440 resulted in cell cycle arrest and apoptotic activity in cell lines of acute erythroid leukemia and acute megakaryoblastic leukemia, and resulted in suppression of tumor growth in xenograft models of both types of cell lines (PMID: 27903753). 27903753
PubMed Id Reference Title Details
(27903753) A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells. Full reference...