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Molecular Profile FGFR3 S249C
Therapy Infigratinib
Indication/Tumor Type urinary system cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 S249C urinary system cancer sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, Truseltiq (infigratinib) decreased Myc expression, induced cell cycle arrest, and inhibited growth of a urinary tract cancer cell line harboring FGFR3 S249C in culture (PMID: 27401245). 27401245
PubMed Id Reference Title Details
(27401245) c-Myc Alteration Determines the Therapeutic Response to FGFR Inhibitors. Full reference...