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Molecular Profile | NOTCH1 wild-type RB1 loss |
Therapy | Ribociclib |
Indication/Tumor Type | T-cell adult acute lymphocytic leukemia |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NOTCH1 wild-type RB1 loss | T-cell adult acute lymphocytic leukemia | resistant | Ribociclib | Preclinical - Cell culture | Actionable | In a preclinical study, a T-cell acute lymphoblastic leukemia cell line harboring wild-type NOTCH1 and loss of RB1 demonstrated resistance to Kisqali (ribociclib) in culture, resulting in limited inhibition of cell growth (PMID: 28151717). | 28151717 |
PubMed Id | Reference Title | Details |
---|---|---|
(28151717) | Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia. | Full reference... |