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|Molecular Profile||PIK3CA K111N|
|Indication/Tumor Type||breast cancer|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PIK3CA K111N||breast cancer||sensitive||ARQ 751||Preclinical - Cell culture||Actionable||In a preclinical study, ARQ 751 treatment did not increase cell death but inhibited proliferation of a breast cancer cell line harboring PIK3CA K111N in culture (PMID: 32439931).||32439931|
|PIK3CA K111N||breast cancer||sensitive||ARQ 751||Preclinical - Cell culture||Actionable||In a preclinical study, a breast cancer cell line harboring PIK3CA K111N was sensitive to ARQ 751 in culture, demonstrating inhibition of cell growth (PMID: 26469692).||26469692|
|PubMed Id||Reference Title||Details|
|(26469692)||Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092.||Full reference...|
|(32439931)||A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity.||Full reference...|