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|Molecular Profile||PTEN loss|
|Indication/Tumor Type||triple-receptor negative breast cancer|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PTEN loss||triple-receptor negative breast cancer||sensitive||M2698||Preclinical - Cell line xenograft||Actionable||In a preclinical study, a triple-receptor negative breast cancer xenograft model harboring PTEN loss was sensitive to M2698 (MSC2363318A), demonstrating inhibition of tumor growth and tumor regression (PMID: 27186432).||27186432|
|PubMed Id||Reference Title||Details|
|(27186432)||M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier.||Full reference...|