Molecular Profile | Unknown unknown |
Therapy | Pracinostat |
Indication/Tumor Type | colon cancer |
Response Type | not applicable |
Create By | spatt |
Update By | spatt |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References | Unknown unknown | colon cancer | not applicable | Pracinostat | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Pracinostat (SB939) inhibited proliferation of colon cancer cell lines in culture, and increased histone H3 acetylation and inhibited tumor growth in a colon cancer cell line xenograft model (PMID: 20197387). | 20197387 |
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PubMed Id | Reference Title | Details |
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(20197387) | SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. | Full reference... |