Profile Response Detail

Molecular Profile KRAS exon 2
Therapy Cetuximab + Selumetinib
Indication/Tumor Type colorectal cancer
Response Type no benefit
Create By spatt
Update By spatt


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS exon 2 colorectal cancer no benefit Cetuximab + Selumetinib Phase I Actionable In a Phase I trial, the combination of Erbitux (cetuximab) and Selumetinib (AZD6244) demonstrated safety, but minimal efficacy, in patients with metastatic colorectal cancer harboring KRAS exon 2 mutations, with no responses and 36% (5/14) of patients achieving stable disease (PMID: 26666244). 26666244
PubMed Id Reference Title Details
(26666244) A phase I study of selumetinib (AZD6244/ARRY-142866), a MEK1/2 inhibitor, in combination with cetuximab in refractory solid tumors and KRAS mutant colorectal cancer. Full reference...