Profile Response Detail

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Molecular Profile TP53 S241F
Therapy DS-7423
Indication/Tumor Type ovarian clear cell adenocarcinoma
Response Type decreased response

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 S241F ovarian clear cell adenocarcinoma decreased response DS-7423 Preclinical - Cell culture Actionable In a preclinical study, an ovarian clear cell adenocarcinoma cell line harboring TP53 S241F demonstrated reduced sensitivity to DS-7423 in culture (PMID: 24504419). 24504419
PubMed Id Reference Title Details
(24504419) Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. Full reference...