Profile Response Detail

Molecular Profile TP53 del
Therapy TC-A2317
Indication/Tumor Type colorectal cancer
Response Type predicted - sensitive
Create By tyin
Update By djd

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 del colorectal cancer predicted - sensitive TC-A2317 Preclinical - Cell culture Actionable In a preclinical study, MK-8745 treatment resulted in polyploidy in TP53-null colorectal cancer cells in culture (PMID: 22293494). 22293494
PubMed Id Reference Title Details
(22293494) The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent. Full reference...