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Molecular Profile | Unknown unknown |
Therapy | A-1155463 + BETd-246 |
Indication/Tumor Type | triple-receptor negative breast cancer |
Response Type | not applicable |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
Unknown unknown | triple-receptor negative breast cancer | not applicable | A-1155463 + BETd-246 | Preclinical - Cell culture | Actionable | In a preclinical study, the Bet inhibitor BETd-246 and the Bcl-xl inhibitor A-1155463 synergistically induced apoptosis in triple-receptor negative breast cancer cell lines in culture (PMID: 28209615). | 28209615 |
PubMed Id | Reference Title | Details |
---|---|---|
(28209615) | Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer. | Full reference... |