Profile Response Detail

Molecular Profile KRAS mutant
Therapy Irinotecan + Reolysin
Indication/Tumor Type colorectal cancer
Response Type sensitive
Create By cstatz
Update By cstatz


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS mutant colorectal cancer sensitive Irinotecan + Reolysin Preclinical - Cell culture Actionable In a preclinical study, the combination of Reolysin (pelareorep) and Camptosar (irinotecan) resulted in a synergistic effect, demonstrating increased apoptotic activity and growth inhibition in colorectal cancer cells harboring a KRAS mutation in culture compared to either agent alone (PMID: 24798549). 24798549
PubMed Id Reference Title Details
(24798549) Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan. Full reference...