Profile Response Detail


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Molecular Profile TP53 mutant
Therapy Doxorubicin + Seliciclib
Indication/Tumor Type triple-receptor negative breast cancer
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 mutant triple-receptor negative breast cancer predicted - sensitive Doxorubicin + Seliciclib Preclinical - Cell line xenograft Actionable In a preclinical study, sequential administration of Roscovotine (seliciclib) followed by Adriamycin (doxorubicin) synergistically induced apoptosis in TP53-mutant triple-receptor negative breast cancer cell lines in culture, and inhibited tumor growth, prolonged survival in cell line xenograft models (PMID: 26826118). 26826118
PubMed Id Reference Title Details
(26826118) Sequential Combination Therapy of CDK Inhibition and Doxorubicin Is Synthetically Lethal in p53-Mutant Triple-Negative Breast Cancer. Full reference...