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Molecular Profile NPM1 exon12
Therapy Ixazomib + Vorinostat
Indication/Tumor Type acute myeloid leukemia
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NPM1 exon12 acute myeloid leukemia sensitive Ixazomib + Vorinostat Preclinical - Cell culture Actionable In a preclinical study, Ixazomib (MLN9708) and Zolinza (vorinostat) synergistically induced apoptosis in NPMc+ (due to NPM1 exon 12 mutations) acute myeloid leukemia cells in culture (PMID: 26634271). 26634271
PubMed Id Reference Title Details
(26634271) Selective Toxicity of Investigational Ixazomib for Human Leukemia Cells Expressing Mutant Cytoplasmic NPM1: Role of Reactive Oxygen Species. Full reference...