Profile Response Detail

Molecular Profile Unknown unknown
Therapy PTC596
Indication/Tumor Type Advanced Solid Tumor
Response Type not applicable
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable PTC596 Phase I Actionable In a Phase I trial, PTC596 demonstrated safety and preliminary efficacy, resulted in stable disease in 16% (5/31) of patients with advanced solid tumors (J Clin Oncol 35, 2017 (suppl; abstr 2574)). detail...
PubMed Id Reference Title Details
Phase 1 results of PTC596, a novel small molecule targeting cancer stem cells (CSCs) by reducing levels of BMI1 protein. Full reference...