Profile Response Detail

Molecular Profile EZH2 F120L EZH2 Y111N
Therapy Tazemetostat
Indication/Tumor Type Advanced Solid Tumor
Response Type resistant
Create By cstatz
Update By cstatz


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EZH2 F120L EZH2 Y111N Advanced Solid Tumor resistant Tazemetostat Preclinical - Cell culture Actionable In a preclinical study, a cancer cell line co-expressing EZH2 F120L and EZH2 Y111N was resistant to Tazemetostat (EPZ-6438) in culture, demonstrating no inhibition of cell proliferation (PMID: 28135235). 28135235
PubMed Id Reference Title Details
(28135235) An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED. Full reference...