Profile Response Detail

Molecular Profile KRAS G12V
Therapy AZD4785
Indication/Tumor Type colorectal cancer
Response Type sensitive
Create By tyin
Update By tyin

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G12V colorectal cancer sensitive AZD4785 Preclinical - Cell culture Actionable In a preclinical study, AZD4785 inhibited Kras expression, resulted in growth inhibition in 3-D cultures of colorectal cancer cell lines harboring KRAS G12V (PMID: 28615361). 28615361
PubMed Id Reference Title Details
(28615361) Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS. Full reference...