Profile Response Detail

Molecular Profile MET amp
Therapy Cetuximab
Indication/Tumor Type colorectal cancer
Response Type resistant
Create By spatt
Update By rajadg


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MET amp colorectal cancer resistant Cetuximab Case Reports/Case Series Actionable In a clinical case study, MET amplification was associated with resistance to Erbitux (cetuximab) in 2 colorectal cancer patients, and in patient-derived xenograft (PDX) models (PMID: 23729478). 23729478
PubMed Id Reference Title Details
(23729478) Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Full reference...