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Molecular Profile | NPM1 mutant |
Therapy | MI-503 |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NPM1 mutant | acute myeloid leukemia | predicted - sensitive | MI-503 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, MI-503 inhibited growth of an acute myeloid leukemia cell line and primary AML samples harboring NPM1 mutations in culture, and reduced tumor burden and improved survival in an NPM1-mutant AML cell line xenograft model (PMID: 27535106). | 27535106 |
PubMed Id | Reference Title | Details |
---|---|---|
(27535106) | Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia. | Full reference... |