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|Molecular Profile||PIK3CA amp|
|Indication/Tumor Type||head and neck squamous cell carcinoma|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PIK3CA amp||head and neck squamous cell carcinoma||sensitive||Dactolisib||Preclinical - Cell culture||Actionable||In a preclinical study, BEZ235 resulted in antiproliferative activity in head and neck squamous cell carcinoma cells harboring PIK3CA amplification in culture (PMID: 28446642).||28446642|
|PubMed Id||Reference Title||Details|
|(28446642)||Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC.||Full reference...|