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Molecular Profile EML4 - ALK CDKN2A del FGFR1 T141R SMAD4 Q83*
Therapy Alectinib
Indication/Tumor Type pancreatic ductal adenocarcinoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK CDKN2A del FGFR1 T141R SMAD4 Q83* pancreatic ductal adenocarcinoma predicted - sensitive Alectinib Case Reports/Case Series Actionable In a clinical case study, a pancreatic ductal adenocarcinoma patient harboring EML4-ALK along with CDKN2A deletion, FGFR1 T141R, SMAD4 Q83*, and a TP53 splice site mutation, experienced disease progression after 2 months of Xalkori (crizotinib) treatment, then received Alecensa (alectinib) and remained on treatment for at least 3 months (PMID: 28476735). 28476735
PubMed Id Reference Title Details
(28476735) Identification of Targetable ALK Rearrangements in Pancreatic Ductal Adenocarcinoma. Full reference...