Profile Response Detail


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Molecular Profile MDM2 amp
Therapy Pembrolizumab
Indication/Tumor Type triple-receptor negative breast cancer
Response Type no benefit


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MDM2 amp triple-receptor negative breast cancer no benefit Pembrolizumab Case Reports/Case Series Actionable In a clinical case study, a patient with triple-receptor negative breast cancer that harbored MDM2 amplification quickly progressed after receiving Keytruda (pembrolizumab), resulted in new chest wall metastasis and a 55% increase of existing lung metastasis size 1.5 months after treatment (PMID: 28351930). 28351930
PubMed Id Reference Title Details
(28351930) Hyperprogressors after Immunotherapy: Analysis of Genomic Alterations Associated with Accelerated Growth Rate. Full reference...