Profile Response Detail

Molecular Profile BRAF G466V
Therapy Trametinib
Indication/Tumor Type colorectal cancer
Response Type sensitive
Create By spatt
Update By spatt

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF G466V colorectal cancer sensitive Trametinib Preclinical - Pdx Actionable In a preclinical study, treatment with Mekinist (trametinib) delayed tumor growth in a colorectal cancer patient-derived xenograft (PDX) model harboring BRAF G466V, and wild-type RAS and NF1 (PMID: 28783719). 28783719
PubMed Id Reference Title Details
(28783719) Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS. Full reference...