Profile Response Detail

Molecular Profile BRAF G466V
Therapy Irinotecan + Panitumumab
Indication/Tumor Type colorectal cancer
Response Type predicted - sensitive
Create By spatt
Update By driscd


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF G466V colorectal cancer predicted - sensitive Irinotecan + Panitumumab Case Reports/Case Series Actionable In a clinical case study, a patient with metastatic colorectal cancer harboring BRAF G466V, and with wild-type RAS and NF1, demonstrated tumor regression following treatment with Vectibix (panitumumab) plus Camptosar (irinotecan) (PMID: 28783719). 28783719
PubMed Id Reference Title Details
(28783719) Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS. Full reference...