Profile Response Detail


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Molecular Profile BRAF mutant
Therapy KO-947
Indication/Tumor Type pancreatic cancer
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF mutant pancreatic cancer predicted - sensitive KO-947 Preclinical - Pdx Actionable In a preclinical study, KO-947 inhibited Erk signaling and induced tumor regression in patient-derived xenograft models of BRAF-mutant pancreatic cancer (Cancer Res 2017;77(13 Suppl):Abstract nr 5168). detail...
PubMed Id Reference Title Details
KO-947, a potent ERK inhibitor with robust preclinical single agent activity in MAPK pathway dysregulated tumors Full reference...