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Molecular Profile DOT1L V293_L296delinsMM
Therapy Pinometostat
Indication/Tumor Type acute myeloid leukemia
Response Type decreased response


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
DOT1L V293_L296delinsMM acute myeloid leukemia decreased response Pinometostat Preclinical - Cell culture Actionable In a preclinical study, a murine acute myeloid leukemia cell line expressing DOT1L V293_L296delinsMM demonstrated reduced sensitivity to EPZ-5676 (pinometostat) in culture (PMID: 28231254). 28231254
PubMed Id Reference Title Details
(28231254) Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis. Full reference...