Profile Response Detail


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Molecular Profile TP53 P98A
Therapy Seliciclib
Indication/Tumor Type lung non-small cell carcinoma
Response Type decreased response


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 P98A lung non-small cell carcinoma decreased response Seliciclib Preclinical - Cell culture Actionable In a preclinical study, non-small cell lung carcinoma cells overexpressing TP53 P98A demonstrated reduced sensitivity to Roscovotine (seliciclib) induced apoptosis in culture (PMID: 22862161). 22862161
PubMed Id Reference Title Details
(22862161) Roscovitine-induced apoptosis of H1299 cells depends on functional status of p53. Full reference...