Profile Response Detail

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Molecular Profile TP53 mutant
Therapy Adavosertib + Carboplatin
Indication/Tumor Type ovarian cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 mutant ovarian cancer predicted - sensitive Adavosertib + Carboplatin Phase II Actionable In a Phase II trial, Paraplatin (carboplatin) and Adavosertib (MK-1775) combination treatment resulted in an overall response rate of 43% (9/21), a median progression-free survival of 5.3 months and a median overall survival of 12.6 months in ovarian cancer patients harboring TP53 mutations (PMID: 27998224; NCT01164995). 27998224
PubMed Id Reference Title Details
(27998224) Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months. Full reference...