Profile Response Detail

Molecular Profile MET amp MET del exon14 MET D1228N MET G1163R MET L1195V
Therapy Glesatinib
Indication/Tumor Type lung adenocarcinoma
Response Type resistant
Create By cstatz
Update By cstatz

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MET amp MET del exon14 MET D1228N MET G1163R MET L1195V lung adenocarcinoma resistant Glesatinib Clinical Study Actionable In a clinical case study, a lung adenocarcinoma patient previously harboring MET amp, MET deletion exon 14, MET D1228N, MET Y1230H, MET Y1230S, and MET G1163R demonstrated a decrease in lesion size when treated with Glesatinib (MGCD265), however, progression ensued and plasma testing indicated the patient lost Y1230H and Y1230S, but acquired MET L1195V (PMID: 28765324). 28765324
PubMed Id Reference Title Details
(28765324) Glesatinib Exhibits Antitumor Activity in Lung Cancer Models and Patients Harboring MET Exon 14 Mutations and Overcomes Mutation-Mediated Resistance to Type I MET Inhibitors in Nonclinical Models. Full reference...