Profile Response Detail


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Molecular Profile ARID1A mutant
Therapy VE-821
Indication/Tumor Type ovarian clear cell carcinoma
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ARID1A mutant ovarian clear cell carcinoma sensitive VE-821 Preclinical - Cell culture Actionable In a preclinical study, ovarian clear cell carcinoma cells harboring an ARID1A mutation were sensitive to VE-821 in in vitro assays, demonstrating decreased cell survival (PMID: 27958275). 27958275
PubMed Id Reference Title Details
(27958275) ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A. Full reference...