Profile Response Detail


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Molecular Profile ARID1A mutant
Therapy Berzosertib
Indication/Tumor Type ovarian clear cell carcinoma
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ARID1A mutant ovarian clear cell carcinoma sensitive Berzosertib Preclinical - Cell line xenograft Actionable In a preclinical study, Berzosertib (VX-970) treatment in ovarian clear cell carcinoma cells harboring an ARID1A mutation resulted in decreased cell survival and induction of DNA damage and apoptosis in culture, and tumor growth inhibition in cell line xenograft models (PMID: 27958275). 27958275
PubMed Id Reference Title Details
(27958275) ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A. Full reference...