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Molecular Profile KIT L576P
Therapy SEL201
Indication/Tumor Type melanoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT L576P melanoma sensitive SEL201 Preclinical - Cell line xenograft Actionable In a preclinical study, SEL201 inhibited MNK pathway signaling and growth of melanoma cells harboring KIT L576P in culture, and suppressed tumor metastasis in xenograft models (PMID: 29035277). 29035277
PubMed Id Reference Title Details
(29035277) MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma. Full reference...