Profile Response Detail

Molecular Profile BRAF amp BRAF V600E
Therapy SCH772984
Indication/Tumor Type lung adenocarcinoma
Response Type decreased response
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF amp BRAF V600E lung adenocarcinoma decreased response SCH772984 Preclinical - Patient cell culture Actionable In a preclinical study, patient-derived BRAF V600E mutant lung adenocarcinoma cells that acquired resistance to Erk inhibitor through BRAF amplification were less sensitive to SCH772984 in culture (PMID: 28714990). 28714990
PubMed Id Reference Title Details
(28714990) An approach to suppress the evolution of resistance in BRAF(V600E)-mutant cancer. Full reference...