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Molecular Profile | Unknown unknown |
Therapy | GNE-781 |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | not applicable |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
Unknown unknown | acute myeloid leukemia | not applicable | GNE-781 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, GNE-781 treatment resulted in tumor growth inhibition and reduced MYC transcript levels in acute myeloid leukemia cell line xenograft models (PMID: 28892380). | 28892380 |
PubMed Id | Reference Title | Details |
---|---|---|
(28892380) | GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). | Full reference... |