Profile Response Detail


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Molecular Profile PIK3CA E545K
Therapy Sirolimus
Indication/Tumor Type Klatskin's tumor
Response Type unknown


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA E545K Klatskin's tumor unknown Sirolimus Phase 0 Actionable In a pilot clinical trial, Rapamune (sirolimus) demonstrated modest clinical activity in patients with PIK3CA-mutant gastric cancer (n=3) or hilar cholangiocarcinoma (n=1; harboring PIK3CA E545K), with a 0% response rate, median progression-free survival of 1.9 months, and median overall survival of 3.6 months (PMID: 28685070). 28685070
PubMed Id Reference Title Details
(28685070) Pilot study of sirolimus in patients with PIK3CA mutant/amplified refractory solid cancer. Full reference...