Profile Response Detail

Molecular Profile FGFR1 amp
Therapy Pazopanib
Indication/Tumor Type Her2-receptor negative breast cancer
Response Type predicted - sensitive
Create By cstatz
Update By driscd


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 amp Her2-receptor negative breast cancer predicted - sensitive Pazopanib Case Reports/Case Series Actionable In a clinical case study, a patient with ERBB2 (HER2)-receptor negative breast cancer harboring FGFR1 amplification demonstrated antitumor activity when treated with Votrient (pazopanib), including a near complete loss of brain lesions and improved function of the liver (PMID: 29223982). 29223982
PubMed Id Reference Title Details
(29223982) Pazopanib Sensitivity in a Patient With Breast Cancer and FGFR1 Amplification. Full reference...