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Molecular Profile BRAF V600E
Therapy PLX4720
Indication/Tumor Type melanoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E melanoma sensitive PLX4720 Preclinical - Cell line xenograft Actionable In a preclinical study, PLX4720 inhibited growth of melanoma cells harboring BRAF V600E in culture and in cell line xenograft models (PMID: 18287029). 18287029
PubMed Id Reference Title Details
(18287029) Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Full reference...