Profile Response Detail

Molecular Profile ERBB2 Y772_A775dup
Therapy Neratinib
Indication/Tumor Type Her2-receptor negative breast cancer
Response Type predicted - sensitive
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 Y772_A775dup Her2-receptor negative breast cancer predicted - sensitive Neratinib Phase II Actionable In a Phase II trial (SUMMIT), Nerlynx (neratinib) treatment resulted in complete response in one patient, and stable disease in 2 patient with Erbb2 (Her2) receptor negative (non-amplified) breast cancer harboring ERBB2 (HER2) Y772_A775dup (PMID: 29420467; NCT01953926). 29420467
PubMed Id Reference Title Details
(29420467) HER kinase inhibition in patients with HER2- and HER3-mutant cancers. Full reference...