Profile Response Detail

Molecular Profile BRAF wild-type KRAS wild-type NRAS wild-type
Therapy Bevacizumab + Cetuximab + Fluorouracil + Irinotecan + Leucovorin
Indication/Tumor Type colorectal cancer
Response Type predicted - sensitive
Create By spatt
Update By spatt


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF wild-type KRAS wild-type NRAS wild-type colorectal cancer predicted - sensitive Bevacizumab + Cetuximab + Fluorouracil + Irinotecan + Leucovorin Phase II Actionable In a Phase II trial (MACBETH), first-line treatment with the combination of Erbitux (cetuximab) and FOLFIRI, followed by Avastin (bevacizumab) maintenance, demonstrated activity in BRAF/KRAS/NRAS wild-type metastatic colorectal cancer patients, resulting in a median overall survival in the intent-to-treat population of 32.2 mo and response rate of 75% (43/57), however, resulted in a 10-mo PFS rate of 40.4% (23/57), which did not meet the primary endpoint of 70% (PMID: 29450468; NCT02295930). 29450468
PubMed Id Reference Title Details
(29450468) Activity and Safety of Cetuximab Plus Modified FOLFOXIRI Followed by Maintenance With Cetuximab or Bevacizumab for RAS and BRAF Wild-type Metastatic Colorectal Cancer: A Randomized Phase 2 Clinical Trial. Full reference...