Profile Response Detail


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Molecular Profile PBRM1 inact mut
Therapy Nivolumab
Indication/Tumor Type clear cell renal cell carcinoma
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PBRM1 inact mut clear cell renal cell carcinoma sensitive Nivolumab Clinical Study - Cohort Actionable In a clinical study, renal clear cell carcinoma patients harboring PBRM1 loss-of-function mutations demonstrated improved response to immune checkpoint therapies including Opdivo (nivolumab) alone or in combination with Yervoy (ipilimumab), and Tecentriq (atezolizumab), potentially due to the distinct expression profile of immune-related genes in these patients (PMID: 29301960). 29301960
PubMed Id Reference Title Details
(29301960) Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. Full reference...