Profile Response Detail


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Molecular Profile FGFR2 - TNS1
Therapy Buparlisib + Infigratinib
Indication/Tumor Type triple-receptor negative breast cancer
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 - TNS1 triple-receptor negative breast cancer sensitive Buparlisib + Infigratinib Preclinical - Cell line xenograft Actionable In a preclinical study, triple-receptor negative breast cancer xenograft models harboring FGFR2-TNS1 demonstrated rapid and complete tumor regression when treated with the combination of Infigratinib (BGJ398) and Buparlisib (BKM120) (PMID: 29203461). 29203461
PubMed Id Reference Title Details
(29203461) Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer. Full reference...