Profile Response Detail

Molecular Profile FGFR2 amp FGFR2-COL14A1
Therapy Derazantinib
Indication/Tumor Type colon cancer
Response Type sensitive
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 amp FGFR2-COL14A1 colon cancer sensitive Derazantinib Preclinical - Cell line xenograft Actionable In a preclinical study, Derazantinib (ARQ 087) inhibited Fgfr signaling and growth of colon cancer cells harboring FGFR2 amplification and FGFR2-COL14A1 fusion in culture and in cell line xenograft models (PMID: 27627808). 27627808
PubMed Id Reference Title Details
(27627808) Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation. Full reference...