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Molecular Profile CTNNB1 S45del
Therapy BAY1217389
Indication/Tumor Type colon carcinoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CTNNB1 S45del colon carcinoma predicted - sensitive BAY1217389 Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colon carcinoma cell line harboring CTNNB1 S45del, demonstrated increased sensitivity to BAY1217389 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540
PubMed Id Reference Title Details
(28751540) TTK Inhibitors as a Targeted Therapy for CTNNB1 (β-catenin) Mutant Cancers. Full reference...